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Henry ascended the Throne in 1509 upon his father's demise. Catherine's father, the Aragonese King Ferdinand II, sought to control England through his daughter, and consequently insisted on her marriage to the new English King. Henry wed Catherine about nine weeks after his accession, despite the concerns of Pope Julius II and William Warham, the Archbishop of Canterbury, regarding the marriage's validity. They were both crowned at Westminster Abbey on 24 June 1509. Queen Catherine's first pregnancy ended in stillbirth in 1510. She gave birth to a son, Henry, in 1511, but he died within two months of his birth.
For about two years after Henry's accession, Richard Fox, the Bishop of Winchester and Lord Privy Seal, and William Warham controlled matters of state. From 1511 onwards, however, power was held by the ecclesiastic Thomas Wolsey. In 1511, Henry joined the Holy League, a body of European rulers opposed to the French King Louis XII. The League also included such European rulers as Pope Julius II, the Aragonian King Ferdinand II and the Holy Roman Emperor Maximilian I. Henry and Ferdinand also signed the Treaty of Westminster. Henry personally joined the English Army as they crossed the English Channel into France, and took part in sieges and battles.
In 1514, however, Ferdinand left the alliance, and the other parties made peace with the French. Irritation towards Spain led to discussion of a divorce with Queen Catherine. However, upon the accession of the French King Francis I in 1515, England and France grew antagonistic, and Henry reconciled with Ferdinand. In 1516, Queen Catherine gave birth to a girl, Mary, encouraging Henry that he could still have a male heir despite his wife's previous failed pregnancies (one stillbirth, one miscarriage and two short-lived infants).
Ferdinand died in 1516, to be succeeded by his grandson—Queen Catherine's nephew— Charles. In 1519, when Maximilian also died, Wolsey—who was by that time a Cardinal—secretly proposed Henry as a candidate for the post of Holy Roman Emperor, though supporting the French King Francis in public. In the end, however, the prince-electors settled on Charles. The subsequent rivalry between Francis and Charles allowed Henry to act as a mediator between them. Henry came to hold the balance of power in Europe. Both Francis and Charles sought Henry's favour, the former in a dazzling and spectacular manner at the Field of Cloth of Gold, and the latter more solemnly at Kent. After 1521, however, England's influence in Europe began to wane. Henry entered into an alliance with Charles V, and Francis I was quickly defeated. Charles's reliance on Henry subsided, as did England's power in Europe.
Henry VIII's accession was the first peaceful one England had witnessed in several years. The Tudor dynasty, however, was a new one; its legitimacy could still be tested. Henry felt that only a male heir could secure the Throne; no Queen had ever ruled England, and the English people seemed distrustful of female rulers. Although Queen Catherine had been pregnant at least seven times (for the last time in 1518), only one child, the Princess Mary, had survived beyond infancy. Henry had previously been happy with mistresses, including Mary Boleyn and Elizabeth Blount, with whom he had had a bastard son, Henry Fitzroy. In 1526, when it became clear that Queen Catherine could have no further children, he began to pursue Mary Boleyn's sister, Anne. Anne was not the chief cause of Henry's attempt to rid himself of Queen Catherine—that designation most likely appertains to Henry's desire for a male heir.
Henry's long and arduous attempt to end his marriage to Queen Catherine became known as "The King's Great Matter." Unbeknownst to Queen Catherine, Cardinal Wolsey and William Warham held an inquiry into the validity of her marriage to Henry. Queen Catherine, however, testified that her marriage to Arthur, Prince of Wales had never been consummated, and that there was therefore no impediment to her subsequent marriage to Henry. The inquiry could proceed no further, and was dropped.
Without informing Cardinal Wolsey, Henry directly appealed to the Holy See. He sent William Knight, his secretary, to Rome to argue that Julius II's Bull was obtained by trickery, and consequently void. In addition, he requested Pope Clement VII to grant a dispensation allowing him to marry any woman, even in the first degree of affinity. (Such a dispensation was necessary because Henry had previously had intercourse with Anne Boleyn's sister Mary.) Knight found that Pope Clement VII was practically the prisoner of the Emperor Charles V. He had difficulty gaining access to the Pope, and when he finally did, he could accomplish little. Clement VII did not agree to annul the marriage, but he did grant the desired dispensation, probably presuming that the dispensation would be of no effect as long as Henry remained married to Catherine.
Being advised of the King's predicament, Cardinal Wolsey sent Stephen Gardiner and Edward Foxe to Rome. Perhaps fearing Queen Catherine's nephew, Charles V, Pope Clement VII originally resisted acquiescing. Foxe was sent back with a commission authorising the commencement of proceedings, but the restrictions imposed made it practically meaningless. Gardiner strove for a "decretal commission," which decided the points of law beforehand, and left only questions of fact to be decided. Clement VII was pressured into accepting the proposal; he permitted Cardinal Wolsey and Lorenzo Cardinal Campeggio to try the case jointly. His decretal commission was issued in secret; it was not to be shown to anybody, and was to always remain in Cardinal Campeggio's possession. Points of law were already settled in the commission: the Papal Bull authorising Henry's marriage to Catherine was to be declared void if the grounds alleged therein were false. For instance, the Bull would be void if it falsely asserted that the marriage was absolutely necessary to maintain the Anglo-Spanish alliance.
Cardinal Campeggio arrived in England in 1528. Proceedings, however, were brought to a halt when the Spanish produced a second document allegedly granting the necessary dispensation. It was asserted that, a few months before he had granted papal dispensation in a public Bull, Pope Julius II had secretly granted the same in a private Brief sent to Spain. The decretal commission, however, only made mention of the Bull; it did not authorise Cardinal Campeggio and Cardinal Wolsey to determine the validity of the Brief. For eight months, the parties wrangled over the authenticity of the Brief. Meanwhile, Queen Catherine appealed to her nephew, Charles V, for support. Charles pressured the Pope into recalling Cardinal Campeggio to Rome in 1529.
Angered with Cardinal Wolsey for the delay, Henry stripped him of his wealth and power. He was charged with præmunire—undermining the King's authority by agreeing to represent the Pope—but died on his way to be tried. With Cardinal Wolsey fell other powerful ecclesiastics in England; laymen were appointed to offices such as those of Lord Chancellor and Lord Privy Seal, which were formerly confined to clergymen.
Power then passed to Thomas Cranmer (who became Archbishop of Canterbury in 1532) and Thomas Cromwell (who became Chancellor of the Exchequer in 1533). On 25 January 1533, Cranmer participated in the wedding of Henry and Anne Boleyn. In May, Cranmer pronounced Henry's marriage to Catherine void, and shortly thereafter declared the marriage Anne valid. The Princess Mary was deemed illegitimate, and was replaced as heiress-presumptive by Queen Anne's daughter, the Princess Elizabeth. Catherine lost the title "Queen," and became the Dowager Princess of Wales; Mary was no longer a "Princess," but a mere "Lady." The Dowager Princess of Wales would die of cancer in 1536.