Home > Paroxetine
4 Chemistry
Paroxetine is chemically identified as (Immediate-Release Tablets / Oral Suspension:) (-)-trans-4R-(4-fluorophenyl)-3S-[(3,4-methylenedioxyphenoxy) methyl]piperidine hydrochloride hemihydrate,
or (Controlled-Release Tablets:) (-)-(3S,4R)-4-[(p-fluorophenyl)-3-[(3,4-methylenedioxy)phenoxy]methyl] piperidine hydrochloride hemihydrate.
Its empirical formula is CAlternative meaning: Carbon (computing Carbon is a chemical element in the periodic table that has the symbol C and atomic number 6. An abundant nonmetallic, tetravalent element, carbon has several allotropic forms: diamonds (hardest known mineral). Bindi19 Hhydrogen helium H Li Full table General Name, Symbol, NumberHydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1 (IA), 1 , s Density, Hardness 0. 0899 kg/m3, NA Appearance colorless Atomic properties Atomic weight 1. 00794 amu Atomic radius (ca20 FFluorine (from L. Fluere meaning "to flow"), is the chemical element in the periodic table that has the symbol F and atomic number 9. It is a poisonous pale yellow, univalent gaseous halogen that is the most chemically reactive and electronegative of all NNitrogen is the chemical element in the periodic table that has the symbol N and atomic number 7. A common normally colorless, odorless, tasteless and mostly inert diatomic non-metal gas, nitrogen constitutes 78 percent of Earth's atmosphere and is a cons OOxygen is the chemical element in the periodic table that has the symbol O and atomic number 8. The element is very common, found not only on Earth but throughout the universe. Molecular oxygen (O, often called free oxygen on Earth is thermodynamically un3, with a molecular weight of 374.8 (329.3703 as free base).
Paroxetine hydrochloride is an odorless, off-white powder, having a melting point range of 120° to 138°C and a solubility of 5.4 mg/mL in water.
5 Pharmacology
Paroxetine is a potent and selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor (SSRI). This activity of the drug on brain neurons is thought to be responsible for its antidepressant effects.
Paroxetine is a phenylpiperidine derivative which is chemically unrelated to the tricyclic or tetracyclic antidepressants. In receptor binding studies, paroxetine did not exhibit significant affinity for the adrenergic (alpha(1), alpha(2), beta), dopaminergic , serotonergic (5HT(1), 5HT(2)), or histaminergic receptors of rat brain membrane. A weak affinity for the muscarinic acetylcholine receptor was evident. The predominant metabolites of paroxetine are essentially inactive as 5-HT reuptake inhibitors.
6 External links
Selective serotonin reuptake inhibitors
