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| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid IUPAC name | |
| CAS number 134523-00-5 | ATC code C10AA05 |
| Chemical formula | (C33H34FN2O5)2Ca•3H2O |
| Molecular weight | 1209.42 |
| Bioavailability | 12% |
| Metabolism | Liver |
| Elimination half life | 14 hours |
| Excretion | Bile |
| Pregnancy category | X |
| Legal status | ? |
| Delivery | ? |
In medicine and pharmacology, atorvastatin (Lipitor® or atorvastatin calcium) is a member of the drug class of statinThe statins form a class of hypolipidemic agents. They are used as pharmaceuticals to lower cholesterol levels in patients at risk for cardiovascular disease because of hypercholesterolemia. Members The statins are (brand names in countries other than thes, used for lowering cholesterolCholesterol is a steroid lipid, found in the cell membranes of all body tissues, and transported in the blood plasma, of all animals. Most cholesterol is produced internally, not dietary in origin. It is present in higher concentrations in tissues which e and thereby preventing cardiovascular diseaseCardiovascular disease refers to all disease which involves the heart and/or blood vessels, arteries, occasionally veins. These problems are most commonly due to consequences of arterial disease, atherosclerosis, atheroma, but also can be related to infec. Atorvastatin inhibits a rate-determining enzymeAn enzyme is a protein, or protein complex, that catalyzes a chemical reaction. Like any catalyst, enzymes work by lowering the activation energy of a reaction, thus allowing the reaction to proceed to its steady state or completion much faster than it ot located in hepatic tissue used in cholesterol synthesis, which lowers the amount of cholesterol produced. This also has the effect of lowering the total amount of LDL cholesterol.
Unlike simvastatinIn pharmacology, simvastatin (Zocor®, Zocor Heart Pro®, marketed by the pharmaceutical company Merck & Co. is the main drug from the class of statins. It is used to control hypercholesterolemia (elevated cholesterol levels) and to prevent cardiovascular d and pravastatinIn medicine and pharmacology, pravastatin Pravachol or Selektine®) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Pravastatin was identified originally in a mold called Nocardia autotrophica, atorvastatin is a completely syntheticThe term synthetic can mean more than one thing. Generally, synthetic means man-made. In philosophy, see Synthetic proposition In chemistry, see Chemical synthesis In linguistics, see Synthetic language. compound.
It is currently being marketed by the pharmaceutical company Pfizer as Lipitor.
Atorvastatin is available as Lipitor in tablet form (10, 20, 40 or 80 mg) for oral administration. Tablets are white, elliptical, and film coated.
Atorvastatin is a competitive inhibitor of HMG-CoA reductase. This enzyme catalyzes the reduction of 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate , which is the rate limiting step in hepatic cholesterol synthesis.
Because cholesterol synthesis decreases, hepatic cells increase the number of LDL receptors on the surface of the cells, which increase the amount of LDL uptake by the hepatic cells, and decreases the amount of LDL in the blood.
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