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Cellular differentiation is a concept from developmental biology describing the process by which cells acquire a " type". The morphology of a cell may change dramatically during differentiation, but the genetic material remains the same, with few exceptions. A cell that is able to differentiate into many cell types is known as pluripotent. These cells are called stem cells in animals and meristematic cells in higher plants. A cell that is able to differentiate into all cell types is known as totipotent. In mammals, only the zygote and early embryonic cells are totipotent, while in plants, many differentiated cells can become totipotent with simple laboratory techniques.
1 Overview
In most multicellular organisms, not all cells are alike. For example, cells that make up the human skin are different from cells that make up the inner organs. Yet, all of the different cell types in the human body are all derived from a single, fertilized egg cell through differentiation. Differentiation is the process by which an unspecialized cell becomes specialized into one of the many cells that make up the body, such as a heart, liver, or muscle cell. During differentiation, certain genes are turned on, or become activated, while other genes are switched off, or inactivated. This process is intricately regulated. As a result, a differentiated cell will develop specific structures and perform certain functions.
Differentiation can involve changes in numerous aspects of cell physiology; size, shape, polarity, metabolic activity, responsiveness to signals, and gene expression profiles can all change during differentiation.
In cytopathologyCytopathology is a branch of pathology that studies and diagnoses diseases on the cellular level. The most common use of cytopathology is the Pap smear, used to detect cervical cancer at an early treatable stage. Two methods of collecting cells for analys the level of cellular differentiation is used as a measure of cancerFor other meanings of Cancer: see Cancer (disambiguation . apoptosis; cancer cells, however, avoid apoptosis. Cancer is a group of related diseases characterized by uncontrolled cell division. Currently, it is believed that cancers arise from both genetic progression.
2 Mammalian cell types
Three basic categories of cells make up the mammalian body: germ cells, somatic cellA somatic cell is a body cell, as opposed to a sex cell or gamete in the germline. Somatic cells can be used in cloning. See also Somatic cell nuclear transfer.s, and stem cells. Each of the approximately 100,000,000,000,000 cells in an adult human has its own copy, or copies, of the genomeGenome is also a popular science book by Matt Ridley. In biology, the genome of an organism is a complete DNA sequence of one set of chromosomes; for example, one of the two sets that a diploid individual carries in every somatic cell. When people say tha, with the only exception being certain cell types that lack nuclei in their fully differentiated state, such as red blood cellRed blood cells are the most common type of blood cell and are the vertebrate body's principal means of delivering oxygen to body tissues via the blood. Red blood cells are also known as erythrocytes from Greek erythros for "red" and kytos for "hollow", ns. The majority of these cells are diploidDiploid cells have two copies of each somatic chromosome (non-sex chromosomes), usually one from the mother and one from the father. Most somatic cells (body cells) of higher organisms are diploid or polyploid (three or more copies of each chromosome, oft, or have two copies of each chromosome. These cells are called somatic cells. This category of cells includes most of the cells that make up the human body, such as skin and muscle cells.
Germ line cells are any line of cells that give rise to gametes—eggs and sperm—and are continuous through the generations. Stem cells, on the other hand, have the ability to divide for indefinite periods and to give rise to specialized
cells. They are best described in the context of normal human development.
Development begins when a sperm fertilizes an egg and creates a single cell that has the potential to form an entire organism. In the first hours after fertilization, this cell divides into identical cells. In humans, approximately four days after fertilization and after several cycles of cell division, these cells begin to specialize, forming a hollow sphere of cells, called a blastocyst. The blastocyst has an outer layer of cells, and inside this hollow sphere, there is a cluster of cells called the inner cell mass . The cells of the inner cell mass will go on to form virtually all of the tissues of the human body. Although the cells of the inner cell mass can form virtually every type of cell found in the human body, they cannot form an organism. These cells are referred to as pluripotent. Pluripotent stem cells undergo further specialization into stem cells that give rise to cells that have a particular function. Examples include blood stem cells that give rise to red blood cells, white blood cells, and platelets, and skin stem cells that give rise to the various types of skin cells. These more specialized stem cells are called multipotent—capable of giving rise to several kinds of cells, tissues, or structures.
