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:The article is about stroke as medical term. For other uses of stroke, see stroke (disambiguation).

A stroke or cerebrovascular accident (CVA) occurs when the blood supply to a part of the brain is suddenly interrupted by occlusion (an ischemic stroke) or by hemorrhage (a hemorrhagic stroke). The former, ischemia, is a reduction of blood flow due to occlusion (an obstruction). The latter, hemorrhagic stroke, occurs when a blood vessel in the brain bursts, spilling blood into the spaces surrounding the brain cells or when a cerebral aneurysm ruptures.

Strokes cause loss of brain function in the affected area. A stroke is a medical emergency.

1 Causes

The ischemic stroke is usually caused by atherosclerosis (hardening) of blood vessels, embolus (a piece of blood clot originating from atherosclerotic plaque or heart) or small artery disease (the occlusion of small cerebral vessels).

Risk factors (for atherosclerosis and small vessel disease) are hypertension (high blood pressure), diabetes mellitus, elevated blood lipid levels and cigarette smoking. High blood pressure is the main cause of stroke. Atrial fibrillation and other arrhythmias can lead to clot formation in the heart, which embolise to the brain. Some forms of thrombophilia (increased coagulation tendency) have a predilection for arterial thrombosis and stroke; these include polycythemia vera and the rare paroxysmal nocturnal hemoglobinuriaParoxysmal nocturnal hemoglobinuria is a rare disease characterised by aplastic anemia, thrombosis and red urine in the morning due to breakdown of red blood cells. Signs and symptoms As the name implies, the hemoglobin appears in urine in attacks (paroxy.

2 Signs and symptoms

The symptoms of stroke are usually easy to spot:

A subgroup loses conciousness as part of the initial presentation. This occurs more often in bleeding than in thrombosis.

A sudden-onset severe headache can denote subarachnoid hemorrhage, which is a stroke-like clinical entity. Some other forms of stroke can feature headaches.

If the symptoms resolve within an hour, or maximum 24 hours, the diagnosis is transient ischemic attack (TIA), and not stroke. This syndrome may be a warning sign, and a proportion of patients develop strokes in the future. Treatment is with aspirin.





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