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In man, it can cause serious illness (such as meningitis or brain abscess) or death in a few people. Diagnosis is generally by taking a spinal tap and culturing it, especially if the cerebrospinal fluidCerebrospinal fluid CSF in short, is the clear fluid that occupies the subarachnoid space (the space between the skull and cortex of the brain). It acts as a "cushion" or buffer for the cortex. Also, CSF occupies the ventricular system of the brain and th appears cloudy.
Cryptococcus neoformans infections have been increasing over the past 10 years because of the onset of AIDS and the expanded use of immunosuppressive drugs. About 5% of people with HIV develop cryptococcosisCryptococcosis is a disease caused by an infection with Cryptococcus neoformans.. Cryptococcosis is also more likely in smokers and in people working outdoors.
Cryptococcus is most common in Africa, often in soil which has been contaminated by bird excrement.