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Under the trade name of Brevibloc , esmolol is a cardio-selective beta-blocker given by slow injection into the veins. It is fast-acting, but also acts for only a short period of time; its primary use is for cardiac arrhythmias.Esmolol decreases the force and rate of heart contractions by blocking beta-adrenergic receptors of the autonomic nervous system, which are found in the heart, lungs and other organs of the body. Esmolol prevents the action of two naturally occurring substances: noradrenaline and adrenaline.