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Because HDL can remove cholesterol from atheroma within arteries, and transport it back to the liver for excretion, they are seen as "good" lipoproteins. When measuring cholesterol, any contained in HDL particles serves as protection to the body's cardiovascular health. (In contrast to "bad" LDL cholesterol.)
HDL are the smallest of the lipoproteins. They are the densest because they contain the highest proportion of protein. The liver synthesises these lipoproteins as empty flattened spherical protein particles. They are capable of picking up cholesterol, carried internally, from cells they interact with. They increase in size as they circulate through the bloodstream, if they internal more cholesterol molecules. Thus it is the concentration of large HDL particles which more accurately reflects protective action, as opposed to the concentration of total HDL particles. This ratio of large HDL to total HDL particles varies widely and is only measured by more sophisticated lipoprotein assays using either electrophoresis, the original method developed in the 1970s or newer NMR spectroscopy methods, developed in the 1990s.
Men tend to have noticeably lower HDL levels, with smaller size & lower cholesterol content, than women. Men also have an increased incidence of atherosclerotic heart disease.
Epidemiological studies have shown that high concentrations of HDL (over 60 mg/dL) have protective value against cardiovascular diseases (such as ischemic stroke and myocardial infarction). Low concentrations of HDL (below 40 mg/dL for men, below 50 mg/dL for women) are a positive risk factor for these atherosclerotic diseases.
The American Heart Association, NIH and NCEP provides a set of guidelines for male fasting HDL levels and risk for heart diseaseIschaemic heart disease is a disease characterized by reduced blood supply to the heart. It is the most common cause of death in most western countries. Ischaemia means a "reduced blood supply". The coronary arteries supply blood to the heart muscle and n.
| Level mgMg or mg or MG may stand for: machine gun Madagascar, ISO country code magnesium Mg MG the car company milligram mg megagram Mg or Ton Lists of two-letter combinations./ dl | Level mmolThe mole (symbol: mol) is one of the seven SI base units and is commonly used in chemistry. It measures the amount of substance of a system and is defined as the amount of substance that contains as many elementary entities as there are atoms in exactly 0/ LThe litre (or liter in US) is a metric unit of volume. The litre is not an SI unit, but is "accepted for use with the International System". The symbol for the litre is the lowercase letter l or the uppercase letter L . A cursive or script small letter l | Interpretation |
| <40 | <1.03 | Low HDL cholesterol, heightened risk for heart disease, <50 is the value for women |
| 40-59 | 1.03-1.52 | Medium HDL level |
| >60 | >1.55 | High HDL level, optimal condition considered protective against heart disease |
More sophisticated labroatory methods measure not just the total HDL but also the range of HDL particles, typically divided into 5 groups by size, instead of just the total HDL concentration as listed above. The largest two groups (most functional) of HDL particles have the most protective effects. The two groups of smallest particles reflect HDL particles which are not actively transporting cholesterol, thus not protective.
See also: cholesterol, low density lipoproteinLow-density lipoprotein LDL refers to a class and range of lipoprotein particles, varying somewhat in their size and contents, which carry cholesterol in the blood and around the body, for use by various cells. It is commonly referred to as bad cholestero
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