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The eldest daughter of Claude, Duke of Guise, head of the French House of Guise, and his wife Antoinette of Bourbon, Marie was married at the age of 19 to Louis of Orleans, Duke of Longueville. They had one son, Francis, before Marie's husband died in June 1537; their second son was born posthumously but did not survive.
In 1538 Marie married King James V of Scotland, himself a widower whose first wife had died two months after their wedding in 1537. James and Marie had two sons, but James lived less than a year, and Robert only two days. Their daughter Mary was born on December 8, 1542, and James died six days later, making Mary queen.
It was Marie de Guise who effectively ruled Scotland as Regent for Queen Mary, whom Marie sent to France when Mary was 5 years old, to be raised with her husband-to-be, the son of the French king Henry II. Marie always consulted with her two powerful brothers in France -- Charles, Cardinal of LorraineCharles of Guise, Cardinal of Lorraine ( 1527 1574) was a French Cardinal and member of the powerful House of Guise. Guise was the son of Claude, Duke of Guise and his wife Antoinette of Bourbon. His sister Mary of Guise was wife of James V of Scotland an, and Francis, Duke of GuiseFrancis, 2nd Duke of Guise ( February 17, 1519 February 24, 1563) was a French soldier and politician. Guise was the son of Claude of Guise and his wife Antoinette of Bourbon. His sister Mary of Guise was wife of James V of Scotland and mother of Mary I o, both of whom held government positions -- so that Scotland and France worked as allies in dealing with other nations.
Marie's regency was threatened, however, by the growing influence of the Scottish Protestants, who effectively deposed her on religious grounds. When Marie died in June 10June 10 is the 161st day of the year in the Gregorian calendar (162nd in leap years), with 204 days remaining. Events 1190 Third Crusade: Frederick I Barbarossa drowns in the Saleph River while leading an army to Jerusalem. 1692 Salem witch trials: Bridge or 11June 11 is the 162nd day of the year in the Gregorian Calendar (163rd in leap years), with 203 days remaining. Events 1184 BC According to the calculations of Eratosthenes, the date that Troy was sacked and burned. 1509 Marriage of King Henry VIII of Engl, 1560, her body was taken back to France and interred at the church in the Convent of Saint-Pierre in Reims, where Marie's sister Renée was the abbess.
Scottish queen consorts Regents