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Sellers, born in Crowbrough, Sussex , earned a bachelor of science degree in ecological science from the University of Edinburgh and a doctorate in biometeorology from Leeds University. Sellers' work in the field of meteorology has focused primarily on computer modelling of climate systems.
Sellers was selected as a NASA astronaut candidate in 1996 and flew his first space mission aboard STS-112 in 2002. On this mission he performed three spacewalks to help install the third piece of the International Space Station structure. He is scheduled to make his next spaceflight on STS-121.