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A proton pump is an integral membrane protein that is capable of moving protons across the membrane of a cell, mitochondrion, or other subcellular compartment, thereby creating a difference or gradient in both pH and electrical charge (ignoring differences in buffer capacity) and tending to establish an electrochemical potential.In bacteria, mitochondria and other ATP-producing organelles, reducing equivalents provided by electron transfer or photosynthesis power this translocation of protons. For example, the translocation of protons by cytochrome c oxidase is powered by reducing equivalents provided by reduced cytochrome c. In the plasma membrane proton ATPase and in the ATPase proton pumps of other cellular membranes, ATP itself powers this transport.
The F0F1 ATP synthaseAn ATP synthase is a general term for an enzyme that can synthesize adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate by utilizing some form of energy. The overall reaction sequence is: :ADP + P → ATP These enzymes of mitochondria and the CF1 ATP synthetase of chloroplasts, in contrast, usually conduct protons from high to low concentration across the membrane while drawing energy from this flow to synthesize ATP.
See also:
- transmembrane ATPase
- active transportIn cell biology, active transport is the mediated transport of biochemicals, and other atomic/ molecular substances, across membranes. Unlike passive transport, this process requires chemical energy. In this form of transport, molecules move against eithe
- cytochromeCytochromes are generally membrane-bound proteins that contain heme groups and carry out electron transport. They are found in the mitochondrial inner membrane of eukaryotes, in the chloroplasts of plants, in photosynthetic microorganisms, and in bacteria
- mitochondrion
- chloroplastChloroplasts are organelles found in plant cells and eukaryotic algae which conduct photosynthesis. Chloroplasts are similar to mitochondria but are found only in plants. Both organelles are surrounded by a double membrane with an intermembrane space; bot
- electron transfer chain
- proton pump inhibitor
- ATP synthase
Biochemistry