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Pyruvate dehydrogenase is an allosteric enzyme that transforms pyruvate into acetyl-CoA which is then used in the citric acid cycle.

It is inhibited when either of the three following ratios are increased: [ATP]/[ADP], [NADH]/[NAD+] and [acetyl-CoA]/[CoASH].

Pyruvate dehydrogenase is actually a big complex composed of 60 subunits: 24 pyruvate dehydrogenase (E1), 24 dihydrolipoyl transacetylase (E2) and 12 dihydrolipoyl dehydrogenase (E3).

The global reaction catalysed by pyruvate dehydrogenase is:

pyruvate + CoA + NAD⁺ ⇒ acetyl-CoA + NADH + H⁺ + CO₂

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Pyruvate dehydrogenasePyruvate dehydrogenase is an allosteric enzyme that transforms pyruvate into acetyl-CoA which is then used in the citric acid cycle. It is inhibited when either of the three following ratios are increased: [ATP]/[ADP], [NADH]/[NAD+] and [acetyl-CoA]/[CoAS	Pyruvate Kinase DeficiencyPyruvate Kinase Deficiency is an inherited autosomal recessive disorder which affects the survival of red blood cells, leading to anemia and liver failure among affected dogs. This inherited disease is characterized by signs of anemia, low energy, and exe

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