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Topics: Pyruvate Kinase Transformation Molecule Phosphoenolpyruvate...

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PyruvatePyruvate CHCOCOO&minus is the ionized form of pyruvic acid. It is an important chemical compound in biochemistry. It is the output of the breakdown of glucose known as glycolysis, and (in aerobic respiration) the main input for the citric acid cycle. Pyruvate kinasePyruvate kinase is an enzyme involved in glycolysis which catalyzes the transformation of phosphoenolpyruvate into pyruvate. This produces one molecule of ATP from ADP. Pyruvate translocasePyruvate translocase is a protein that transports selectively pyruvate across the inner membrane of the mitochondrion. Pyruvate dehydrogenasePyruvate dehydrogenase is an allosteric enzyme that transforms pyruvate into acetyl-CoA which is then used in the citric acid cycle. It is inhibited when either of the three following ratios are increased: [ATP]/[ADP], [NADH]/[NAD+] and [acetyl-CoA]/[CoAS Pyruvate Kinase DeficiencyPyruvate Kinase Deficiency is an inherited autosomal recessive disorder which affects the survival of red blood cells, leading to anemia and liver failure among affected dogs. This inherited disease is characterized by signs of anemia, low energy, and exe