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Early season episodes focused on criminal investigation; a typical episode would find Quincy determining the real murderer in a crime, or the real cause of an unusual poisoning case. Later season episodes began to introduce themes of social responsibility; Quincy would find himself involved with a police investigation that reveals a disreputable plastic surgeon and the reasons his poor surgery aren't stopped, flaws in drunk driving laws, or airline safety, and makes a point about what ought be done about it. Quincy, M.E. was one of the earlier dramatic series to use a format like this to suggest a social agenda.
Although Quincy studies bodies in-depth at his lab, he also does plenty of police investigation work technically outside the role of a coroner for the purposes of the show. He works with Dr. Sam Fujiyama, lives on a houseboat, and is popular with ladies.
The show was based on a Canadian series, Wojeck, broadcast by the Canadian Broadcasting Corporation in the 1960s.