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It is used in the termination of pregnancies less than fifty days from conception. A typical dose is 600 mg orally, followed after 48 hours by another 400 mg dose or an oral prostaglandin analogue. Within four hours of the second dose, it is between 92% and 99% effective (depending on the trial data examined), while as a standalone agent it is approximately 80% effective.
It works by competitive interaction with both endogenous and exogenous progesterone at receptor sites. It also has slight antiglucocorticoid and antiandrogenic effects in larger doses.
Mifepristone is a white powder, highly soluble in methanol and only poorly soluble in water. Its structural name is 11β-[p-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one. Its empirical formula is C29H35NO2
It is contraindicated in cases of ectopic pregnancy, adrenal failure, hemorrhagic disorders, anticoagulant or corticosteroid therapy. Side effects include an expected amount of abdominal pain and vaginal bleeding, with the possibility of nausea, vomiting and feverFever also known as pyrexia is a medical symptom which describes an increase in temperature to levels which are above normal (37 degrees Celsius 98. 6 degrees Fahrenheit). An adaptive mechanism, fever is the body's reaction to pathogens; it attempts to ki. Incomplete termination of a pregnancy would require further intervention by a doctor (such as vacuum aspiration ).
The compound was discovered by researchers at Roussel Uclaf of FranceThe French Republic or France ( French: Republique francaise or France is a country whose metropolitan territory is located in western Europe, and which is further made up of a collection of overseas islands and territories located in other continents. in 19801980 is a leap year starting on Tuesday. Events January-February January 1- April 1 National steel strike in United Kingdom January 1 Changes to the Swedish Act of Succession creates Victoria of Sweden, Crown Princess over her younger brother January 5 He while studying glucocorticoid receptor antagonists. Clinical testing began in 1982Events January January 6 William Bonin is convicted of being the "freeway killer". January 8 AT&T agrees to divest itself of twenty-two subdivisions January 11 Mark Thatcher, son of the British Prime Minister Margaret Thatcher, disappears in the Sahara du. It was first licensed in FranceThe French Republic or France ( French: Republique francaise or France is a country whose metropolitan territory is located in western Europe, and which is further made up of a collection of overseas islands and territories located in other continents. in 19881988 is a leap year starting on Friday (click on link for calendar). Events January January 2 Georgia celebrates its bicentennial statehood. January 9 Connecticut celebrates its bicentennial statehood. January 26 Australia celebrates its bicentennial day., for use in combination with prostaglandin. Then on October 26October 26 is the 299th day of the year (300th in leap years) in the Gregorian Calendar, with 66 days remaining. Events 740 An earthquake strikes Constantinople, causing much damage and death. 1640 The Treaty of Ripon is signed, restoring peace between Sc of that year, Roussel Uclaf stated that it would abandon distribution of the drug. It bowed to pressure from the government of France two days later to resume distribution. Mifepristone was approved in a number of other European countries in the 1990sCenturies: 19th century 20th century 21st century Decades: 1940s 1950s 1960s 1970s 1980s 1990s 2000s 2010s 2020s 2030s 2040s Years: Events and trends Computers, technology Explosive growth of the Internet; decrease in the cost of computers and other techn: for example, the United KingdomThe United Kingdom of Great Britain and Northern Ireland is a state in Western Europe, usually known simply as the United Kingdom the UK Britain or less accurately as Great Britain . The UK was formed by a series of Acts of Union which united the formerly approved its use in 1991.
It was approved by the U.S. Food and Drug Administration (FDA) in September 2000. Early research was difficult, as Roussel Uclaf did not seek U.S. approval. It was further interrupted when the first Bush administration banned the importation of mifepristone in 1989. This ban was not reversed until 1993. In 1994, Roussel Uclaf gifted the U.S. drug rights to the Population Council and the drug went on approvable status from 1996. Production was intended to begin through the Danco Group in 1996 but they withdrew briefly in 1997, delaying availability again.
Mifepristone has been investigated in the treatment of Cushing's syndrome and a number of cancers.
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