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The show first aired in 1990 with MIT professor Woodie Flowers who served as the original host from 1990 to the spring of 1993. The affable Alan Alda became the permanent host starting in the fall season of 1993 and has continued ever since.
Most programs include about three shorter documentaries, but some shows follow a different pattern. The show has been popular among people interested in science and technology. Some early viewers of the program who were young at the time have ended up appearing as guests in newer episodes, often stating that the program inspired them to continue their scientific pursuits.