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Home > Theophylline

Theophylline is a drug, a phosphodiesterase (PDE) inhibitorA phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine mono, that is widely used in therapy for respiratory diseases. It bears structural and pharmacological similarity to caffeineCaffeine is an alkaloid found naturally in such foods as coffee beans, tea, kola nuts, Yerba mate, guarana, and (in small amounts) cacao beans. It is added to some soft drinks such as colas and Mountain Dew. Caffeine has a characteristic intensely bitter. It is naturally found in black teaBlack tea is a tea made from leaves more heavily oxidized than the white, green, and oolong varieties. It is generally stronger in flavor and contains more caffeine than more lightly oxidized teas. In Chinese and culturally related languages, black tea is and green teaGreen tea is tea that has undergone minimal oxidation during processing. Green tea is popular in China and Japan, and recently has become more popular in the West, which traditionally drank only black tea. Chinese green teas Grades of Chinese green tea (.

The main actions of theophylline are:

• relaxation of bronchial smooth muscleSmooth muscle is a type of non- striated muscle, found within the " walls" of hollow organs; such as blood vessels, bladders, uteri. gastrointestinal tracts, Smooth muscle is used to move matter withintraction|contraction]]; it generally operates " involu
• positive inotropic effect
• positive chronotropic effect
• lowers blood pressureBlood pressure or arterial blood pressure is the pressure (force per unit area) exerted by the blood on the walls of the blood vessels. Unless indicated otherwise, blood pressure refers to the pressure in the large arteries, such as the brachial artery (i
• increases renalThe kidneys are bean-shaped excretory organs in vertebrates. Part of the urinary system, the kidneys filter wastes (especially urea) from the blood and excrete them, along with water, as urine. The medical field that studies the kidneys and diseases affec blood flow
• some anti-inflammatoryInflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. Inflammation is characterized by the following quintet: redness rubor , heat calor , swelling tumor , pain dolor and dysfuncti effect

The use of theophylline is complicated by the fact that it interacts with various drugs, chiefly cimetidine and phenytoin

The main therapeutic uses of theophylline are:

• chronic obstructive diseases of the airways
  • chronic obstructive pulmonary disease COPD
  • bronchial asthma

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TheophyllineTheophylline is a drug, a phosphodiesterase (PDE) inhibitor, that is widely used in therapy for respiratory diseases. It bears structural and pharmacological similarity to caffeine. It is naturally found in black tea and green tea. The main actions of the